Publications

1. Eugenín E. A. (1996) Regulación de los almacenes de glicógeno por norepinephrine en la glándula pineal de rata: papel de las uniones en hendidura. VI + 67 pp. Undergraduate Thesis.

2. Eugenín E.A., Sáez G.C., Garcés G. and Sáez J.C. (1997) Regulation of the rat pineal gland glycogen content by norepinephrine. Brain Research. 760 (1,2); 34-41.

3. Eugenín E. A., Gonzalez H., Sáez C. G. and Sáez J. C. (1998) Gap junctional communication coordinate vasopressin-induced glycogenolysis in rat hepatocytes. Am. J. Physiol 274 (6); G 1109-1116.

4. Bitran M., Tapia W., Eugenín E. A., Orio P., and Boric M. P. (1999) Neuropeptide Y induced inhibition of noradrenaline release in the rat hypothalamus: Characterization of receptor subtype and role of nitric oxide. Brain Research, 851 (1,2); 87-93.

5. Saez J.C., Brañes M.C., Corvalan L.A., Eugenín E.A., Gonzalez H., Martinez A.D. and Palisson F. (2000) Gap junctions in cells of the immune system: structure, regulation, and possible functional roles. Brazilian Journal of Medical and Biological Research. 33: 447-455.

6. Saez J.C. Araya R., Brañes M.C., Concha M., Contreras J., Eugenín E.A., Martinez A.D., Palisson F. and Sepulveda M.A. (2000) Gap junctions in inflammatory responses: connexins, regulation, and possible functional roles. Current Topics in Membranes. 49: 555-576.

7. Eugenín E.A., Eckcart D., Theis M., Willecke K., Bennett M.V. and Sáez J.C. (2001) Microglia at brain stab wounds express connexin43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proc. Natl. Acad. Sci. USA 98 (7), 4190-4195.

8. Dougnac A., Riquelme A., Calvo M., Andresen M., Magedzo A., Eugenin E., Marshall G., and Gutierrez. (2001) Study of cytokines kinetics in severe sepsis and its relationship with mortality and score of organic dysfunction. Rev. Med. Chil. 129 (4), 347-358.

9 Contreras J., Sánchez H., Eugenin E.A., Spiedel D., Theis M., Willecke K., Bukauskas F.F., Bennett M.V and Sáez J.C. (2002) Metabolic inhibition induces opening of unopposed connexin43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc. Natl. Acad. Sci. USA. 99 (1) 495-500

10. Gonzalez H., Eugenín E. A., Garces G., Solis N., Pizarro M., Accatino L. and Sáez J. C. (2002) Regulation of hepatic connexins during cholestasis: the involvement of some cellular and humoral inflammatory mediators. Am. J. Physiol. 282 (6) G991-G1001.

11. Martinez A. D., Eugenín E. A., Brañes M.C., Bennett M.V., and Sáez J.C. (2002) Identification of a second messenger pathway that induces the expression of functional gap junctions in cultured newborn rat microglia. Brain Research. 943 (2) 191-201.

12. Eugenin E.A., Branes M.C., Berman J.W. and Saez J.C. (2003) TNF- plus IFN-induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. J Immunology. 170: 1320-1328.

13. Eugenin E.A. and Berman J.W. (2003) Chemokine dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier. Methods. 29, 351-361.

14. Saez C.G., Velasquez L., Montoya M., Eugenin E.A. and Alvarez M.G. (2003) Increased Gap junctional intercellular communication is directly related to the anti-tumor effect of all-trans retinoic acid plus tamoxifen in a human mammary cell line. J Cellular Biochemistry. 89: 450-461.

15. Eugenin E.A., D’Aversa T., Lopez L., Calderon T. and Berman J.W. (2003) MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. Journal of Neurochemistry. 85: 1299-1311.

16. Eugenin E.A., Dyer G., Calderon T.M. and Berman J.W. (2005) HIV-1 tat protein induces migration of human fetal microglia by a mechanism CCL2 (MCP-1) dependent. Possible role of microglial axis CCL2-CCR2 in NeuroAIDS.  Glia 49: 501-510.

17. D’Averza T.G., Eugenin E.A., Berman J.W. (2005) NeuroAIDS: Contributions of HIV-1 proteins tat and gp120, and CD40 to microglial activation. J. Neuroscience Res. 81: 436-46.

18. Eugenin E.A., Gamss R., Buckner C., Buono D., Klein R., Schoenbaum E.E., Calderon T.M. and Berman J.W. (2006) Shedding of PECAM-1 during HIV-infection: A role for sPECAM-1 in NeuroAIDS and in the pathogenesis of dementia. J Leukocyte Biology. 79: 444-452.

19. King J.E., Eugenin E.A., Buckner C. and Berman J.W. (2006) New insights in HIV-tat induced neurotoxicity. Microbes and Immunity. 8: 1347-1357.

20. Eugenin E.A., Osiecki K., Lopez L., Goldstein H., Calderon T.M. and Berman J.W. (2006) CCL2/MCP-1 mediates enhanced transmigration of HIV-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS. J. Neuroscience. 26:1098-106

21. Buckner C., Luers A., Calderon T., Eugenin E.A. and Berman J.W. (2006) Neuroimmunity and the Blood Brain Barrier: The Molecular Regulation of Leukocyte Transmigration and Viral Entry into the Nervous System with a Focus on NeuroAIDS. J Neuroimmune Pharmacol.1 (2) 160-181.

22. Calderon T.M., Eugenin E.A., Lopez L., Hesselgesser J., Raine C.S. and Berman J.W. (2006) Upregulation of SDF-1a by astrocytes and endothelial cells in multiple sclerosis lesions: Mechanism of induction by myelin basic protein. J. Neuroimmunology. 177(1-2): 27-39.

23. Eugenin E. A., King J.E., Nath A., Calderon T. M., Zukin S.R., Bennett M.V.L, and Berman J. W. (2007) HIV-tat induces the formation of an LRP-PSD95-NMDAR-nNOS complex necessary for neuronal apoptosis. Proc. Natl. Acad. Sci. USA, 104 (9)3438-3443.

24. Eugenin E.A., Gonzalez H., Sanchez H., Branes M.C. and Saez J.C. (2007) Inflammatory conditions induce gap junctional communication between Kupffer cells both in vivo and in vitro. Cell Immunology. 247(2):103-10.

25. Eugenin E.A. and Berman J.W. (2007) Gap junctions mediate HIV-bystander killing in astrocytes. J. Neuroscience. 27 (47): 12844-50.

26. Dougnac A., Castro R., Riquelme A., Calvo M., Eugenin E., Arellano M., Pattillo M., Regueira T., Mercado M., and Andresen M. (2007) Pro and anti-inflammatory balance of septic patients is associated with severity and outcome. Crit. Care & Shock, 10: 99-107.

27. D’Aversa T.G., Eugenin E.A. and Berman J.W. (2008) CD40-CD40L interactions in human microglia induces CXCL18 (IL-8) secretion by a mechanism dependent on activation of ERK1/2, and nuclear translocation of NF-kB and AP-1. J. Neurosci. Res. 86 (3):630-639.

28. Eugenin E.A., Morgello S., Klotman M.E., Mosoian A., Lento P.A., Berman J.W., and Schecter A.D. (2008) HIV infects human arterial smooth muscle cells in vivo and in vitro: Implications for the pathogenesis of HIV-mediated vascular disease. American Journal of Pathology.172 (4), 1100-11.

29. Rao V.R., Eugenin E.A., Berman J.W. and Prasad V.R. (2009) Methods to study monocyte migration induced by HIV-infected cells.  Prasad and Kalpana Editors, in HIV protocols by Humana Press. 485:295-309.

30. Opazo C., Gianini A., Pancetti F., Azkcona G., Noches V., Gonzalez P., Porto M., Rosenthal D., Eugenin E., Kalergis A., and Riedel C.A. (2008) Maternal Hypothyroxinemia impairs Spatial Learning and Synaptic nature and function in the Offspring. Endocrinology. 149(10):5097-106.

31. Rao V.R., Sas A., Eugenin E., Siddappa N.B., Bimonte-Nelson H., Berman J.W. Ranga U., Tyor W.R. and Prasad V.R. (2008) HIV-1 clade-specific differences in the induction of neuropathogenesis. J Neuroscience. 28 (40), 10010-10016.

32. Eugenin E.A., Gaskill P.J., and Berman J.W. (2009) Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking. Cellular Immunology.254 (2);142-148.

33. Bueno S., Gonzalez P., Cautivo K., Mora J., Leiva E., Tobar H., Fennelly G., Eugenin E.A., Jacobs W., Riedel C., Kalergis A. (2009) Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG. Proc. Natl. Acad. Sci. USA. 105(52):20822-7

34. Eugenin E.A., Gaskill P.J., and Berman J.W. (2009) Tunneling nanotubes (TNT): a potential mechanism for intercellular trafficking. Communicative & Integrative Biology. 2(3): 243-4.

35. Gaskill P.J., Calderon T.M., Luers A.J., Eugenin E.A., Javitch J.A., and Berman J.W. (2009) HIV infection of human macrophages is increased by dopamine; a bridge between HIV associated neurologic disorders and drug abuse. Am J. Pathology. 175(3)1148-59.

36. Agiostratidou G., Suyama K.,Badano I., Keren R., Chung S., Anzovino A., Hulit J., Qian B., Bouzahzah B., Eugenin E., Loudig O., Phillip G.R., Locker J. and Hazan R.B. (2009) Loss of retinal cadherin facilitates mammary tumor progression and metastasis. Cancer Res. 69(12): 5030-8.

37. Hazleton J.E., Berman J.W., and Eugenin E.A. (2010) Novel mechanism of central nervous system damage in HIV infection. HIV/AIDS-Research and Palliative Care. 2, 39-49.

38. King J.E., Eugenin E.A., Hazleton J.E., Morgello S. and Berman J.W. (2010) Mechanisms of HIV-Tat Induced phosphorylation of NMDA Receptor Subunit 2A in Human Primary Neurons:  Implications for NeuroAIDS Pathogenesis. Am. J Pathology. 176(6) 2819-30.

39. Roberts T.K., Eugenin E.A., Morgello S., Clements J.E, Zink M.C., and Berman J.W. (2010) PrPC, the Cellular Isoform of the Human Prion Protein, is a Novel Marker of HIV-Associated Neurocognitive Impairment and Modulates Neuroinflammation. American J. Pathology. 177(4) 1848-60.

40. Eugenin E.A., King J.E., Hazleton J.E., Major E.O., Bennett M.V.L., Zukin R.S. and Berman J.W. (2011) Differences in NMDA receptor expression during development determine the response of neurons to HIV-tat mediated neurotoxicity. Neurotoxicity Research. 19 (1) 138-48.

41. Roberts T.K., Eugenin E.A., Romero I.A., Weksler B.B., Couraud P-O. and Berman J.W. (2012) CCL2 disrupts the adherens junction and increases blood-brain barrier permeability. Laboratory Investigation. 92(8): 1213-33.

 42. Eugenin E.A., Clements J.E, Zink M.C., and Berman J.W. (2011) HIV infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism. The Journal of Neuroscience. 31(26):9456-65.

43. Coniglio S.J., Eugenin E., Dobrenis K., Stanley E.R., West B.L., Symons M.H., and Segall J.E. (2012) Microglial stimulation of glioblastoma invasion involves EGFR and CSF-1R signaling. Molecular Medicine. 18(1):519-27. doi: 10.2119/molmed.2011.00217

44. Cortez C., Eugenin E., Aliaga E., Carreno L.J., Bueno S.B., Gonzalez P., Gayol S., Naranjo D., Noches V., Marassi M.P., Rosenthal D., Jadue C., Ibarra C., Ibarra P., Keitel C., Wohllk N., Kalergis A.M. and Riede C.A. (2012) Hypothyroidism in the adult rat causes an increment of BDNF in the brain, neuronal and astrocyte apoptosis, gliosis and deterioration of the postsynaptic density. Thyroid, 22(9):951-63.

45. D’Aversa T., Eugenin E., Lopez L., and Berman J.W. Myelin basic protein induces inflammatory mediators from primary human endothelial cells and blood-brain barrier disruption: Implications for the pathogenesis of multiple sclerosis. Neurobiology of Disease. In Press, doi: 10.1111/j.1365-2990.2012.01279.x.

46. Hazleton J.E., Berman J.W. and Eugenin E.A. (2012) Purinergic Receptors are required for HIV-1 Infection of Primary Human Macrophages. J. Immunology. 188(9):4488-95.

47. Chung S, Yao J, Suyama K, Bajaj S, Qian X, Loudig OD, Eugenin EA, Phillips GR, Hazan RB. (2012) N-cadherin promotes breast cancer cell migration by suppressing Akt3 expression. Oncology.  In press. doi: 10.1038/onc.2012.65.

48. Williams D., Eugenin E. A., Calderon T.M. and Berman J.W. (2012) Monocyte Maturation, HIV Susceptibility, and Transmigration Across the Blood-Brain Barrier are Critical in HIV Neuropathogenesis. J. Leukocyte Biology. 91(3):401-15

49. Eugenin EA, Basilio D, Sáez JC, Orellana JA, Raine CS, Bukauskas F, Bennett MV, Berman JW. (2012) The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System. J Neuroimmune Pharmacol. 7(3): 499-518.

50. Roberts TK, Eugenin EA, Lopez L, Romero IA, Weksler BB, Couraud PO, Berman JW. (2012) CCL2 disrupts the adherens junction: implications for neuroinflammation. Lab Invest. 2012 May 28. doi: 10.1038/labinvest.2012.80. [Epub ahead of print]

51. Qian X., Hulit J., Suyama K., Eugenin E.A., Belbin T.J., Loudig O., Smirnova T., Zhou Z.N., Segall J., Locker J., Phillips G.R., Norton L., Hazan R.B. (2012). P21CIP1 mediates reciprocal switching between proliferation and invasion during metastasis. Oncogene, 2012 Jul 2. doi: 10.1038/onc.2012.249.

52. Gaskill P.J., Carvallo L., Eugenin E.A., Berman J.W. (2013) Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.  J Neuroinflammation. 18;9(1):203.

53. Orellana JA., Williams D.W., Saez J.C., Berman J.W., and Eugenin E.A. (2013) Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes. J Leukocyte Biology. 94(3):399-407.

54. Eugenin E.A., Greco J.M., Frases S., Nosanchuk J.D., and Martinez L.R. (2013) Methamphetamine alters blood-brain barrier protein expression facilitating central nervous system infection by neurotropic Cryptococcus Neoformans.  Journal Infectious Disease, 208(4); 699-704.

55.  Liu Tong-Bao., Kim J-C., Wang Y., Toffaletti D.L., Eugenin E., Perfect J., Kim K.L., Xue Chaoyang. Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. Plos Pathogens. 9(4).

56. Williams D., Calderon T.M., Lopez- L, Carvallo L., Gaskill P., Eugenin E.A., Morgello S., and Joan Berman. (2013) Mechanisms of HIV Entry Across the Blood-Brain Barrier by CD14+CD16+ Monocytes: Important Roles for JAM-A, ALCAM, and CCR2. Plos Pathogens. 8 (7).

57. Megra B., Eugenin E.A, Roberts T., Morgello S., and Berman J.W. (2013) Protease resistant protein cellular isoform (PrPc) as a biomarker: clues into the pathogenesis of HAND.  Journal Neuroimmune Pharmacology. 8(5); 1159-66.

58. Mavrianos J., Berkow E., Desai C., Pandey A., Batish M., Rabadi M., Barker K., Pain D., Rogers P., Eugenin E.A., and Chauhan N. (2013) Mitochondrial two-component signaling systems in Candida albicans. Eukaryotic Cell. 12(6):913-22.

59. Rao V.R., Neogi U., Talboom J.S., Padilla L., Rahman M., Fritz-French C., Gonzalez-Ramirez S., Verma A., Wood C., Ruprecht R.M., Ranga U., Azim T., Joska J., Eugenin E., Shet A, Bimonte-Nelson H., Tyor W.R., and Prasad V.R. (2013)Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology. 10 (61).

60. Albornoz E.A., Carreño L.J., Cortés C., Gonzalez P.A., Cisternas P.A., Cautivo K.M., Catalan T.P., Opazo M.C., Eugenin E.A., Berman J.W., Bueno S.M., Kalergis A.M., Riedel C.A. (2013) Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring. Thyroid, 23(12) 1627-37.

61. Eugenin E.A. (2013) Community-acquired pneumonia infections by Acinetobacter baumannii: How does alcohol impact the antimicrobial functions of macrophages? Virulence, 4(6): 435-436.

62. Patel D, Desai GM, Frases S, Cordero RJ, DeLeon-Rodriguez CM, Eugenin EA, Nosanchuk JD, Martinez LR. (2013) Methamphetamine enhances Cryptococcus neoformans pulmonary infection and dissemination to the brain. mBio, 4(4).

63. Williams D.W., Calderon T.M., Lopez L., Carvallo-Torres L., Gaskill P.J., Eugenin E.A., Morgello S., Berman J.W. (2013) Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14(+)CD16(+) Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis. Plos One, 8(7).

64. Eugenin E.A. and Berman J.W. (2014) Cytochrome C dysregulation induced by HIV infection of astrocytes result in bystander apoptosis of uninfected astrocytes by an IP3 and Calcium-dependent mechanism. J Neurochemistry, 127 (5): 644-51.

65. Orellana J.A., Saez J.C., Bennett M.V., Berman J.W., Morgello S. and Eugenin E.A. (2014) HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel dependent mechanism. J Neurochemistry. 128 (5): 752-63.

66. Eugenin E.A. (2014) Role of connexins/pannexin containing channels in infectious diseases. FEBS letters. 588 (8) 1389-95.

67. Velasquez S. and Eugenin E.A. (2014) Role of pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases. Front Physiology. 14 (5) 96-118.

68. Castellano P and Eugenin E.A. (2014) Regulation of gap junction channels by infectious agents and inflammation in the CNS. Frontier in Cell NeuroScience. 9; 8; 122-138.

69. Cheshenko N., Trepanier J.B., Gonzalez P.A., Eugenin E.A., Jacobs W.R. Jr., and Herold B.C. (2014) Herpes Simplex Virus Type 2 glycoprotein H interacts with integrin alphaVBeta3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells. J. Virology. 88(17) 10026-38.

70. Rella C., Ruel N., and Eugenin E.A. (2014) Development of imaging techniques to study the pathogenesis of BSL2/3 infectious agents. Pathogens and Disease. 72(3) 167-73.

71. Subbian S., Eugenin E., and Kaplan G. (2014) Detection of Mycobacterium Tuberculosis in lately infected lungs by immunohistochemistry and confocal microscopy. J. Med. Microbiol. 63 (Pt11) 1432-5.

72. Rao V.R., Neogi U., Eugenin E, and Prasad VR. (2014) The gp120 protein is a second determinant of decreased neurovirulence of Indian HIV-1C isolates compared to southern African HIVC isolates. PLOSone. 9(9) doi: 10.1371/journal.pone.0107074. collection 2014.

73. Liu TB, Subbian S, Pan W, Eugenin E, Xie J, Xue C. Cryptococcus inositol utilization modulates the host protective immune response during brain infection. Cell Commun Signal. 2014 Sep 10;12:51. doi: 10.1186/s12964-014-0051-0.

74. Daep C.A. Munos-Jordan JL., and Eugenin E.A. (2014) Flaviviruses, an expanding threat in public health: focus in Dengue, West Nile virus and Japanese encephalitic virus. J. Neurovirol. 20(6) 539-60.

75. Coley JS, Calderon TM, Gaskill PJ, Eugenin EA, Berman JW. (2015) Dopamine increases CD14CD16 monocyte migration and adhesion in the context of substance abuse and HIV neuropathogenesis. PLoS One. 2015 Feb 3;10(2):e0117450. doi: 10.1371/journal.pone.0117450. eCollection 2015.

76. Carvallo L, Lopez L, Che FY, Lim J, Eugenin EA, Williams DW, Nieves E, Calderon TM, Madrid-Aliste C, Fiser A, Weiss L, Angeletti RH, Berman JW. (2015) Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. J Immunol. 2015 Apr 1;194(7):3246-58. doi: 10.4049/jimmunol.1302647. Epub 2015 Feb 25.

77. Nosanchuck J., Eugenin E.A., Martinez L. (2015) Methamphetamine alters the antimicrobial efficacy of phagocytic cells during methicillin-resistant Staphylococcus Aureus skin infection. MBio, 6(6): e01622-15.

78. Valere K, Rapista A, Eugenin E, Lu W, Chang TL. (2015) Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission. Viral Immunol. 28(10):609-15. doi: 10.1089/vim.2014.0137.

79. McFarren A, Lopez L, Williams DW, Veenstra M, Bryan RA, Goldsmith A, Morgenstern A, Bruchertseifer F, Zolla-Pazner S, Gorny MK, Eugenin EA, Berman JW, Dadachova E. (2016) A fully human antibody to gp41 selectively eliminate HIV-infected cells that transmigrated across a model human blood-brain barrier. AIDS. 30(4):563-72.

80. Shi L, Salamon H, Eugenin EA, Pine R, Cooper A, Gennaro ML. (2015)  Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs.  Sci Rep. 5:18176. doi: 10.1038/srep18176.

81. Eugenin EA, Berman JW. (2016) Improved Methods to Detect Low Levels of HIV Using Antibody-Based Technologies. Methods Mol Biol. 1354:265-79. doi: 10.1007/978-1-4939-3046-3_18.

82. Rao VR, Eugenin EA, Prasad VR. (2016) Evaluating the Role of Viral Proteins in HIV-Mediated Neurotoxicity Using Primary Human Neuronal Cultures. Methods Mol Biol. 1354:367-76. doi: 10.1007/978-1-4939-3046-3_25.

83. Berman JW, Carvallo L, Buckner CM, Luers A, Prevedel L, Bennett MV, Eugenin EA. (2016) HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS. J Neuroinflammation. 13(1):54. doi: 10.1186/s12974-016-0510-1.

84. Avdoshina V, Fields JA, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, Mocchetti I. (2016) The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotox Res. 29(4):583-93. doi: 10.1007/s12640-016-9608-6.

85. Castellano P, Nwagbo C, Martinez LR, Eugenin EA. (2016) Methamphetamine compromises gap junctional communication in astrocytes and neurons. J Neurochem. 137(4):561-75. doi: 10.1111/jnc.13603.

86. Malik S, Eugenin EA. (2016) Mechanisms of HIV Neuropathogenesis: Role of Cellular Communication Systems. Curr HIV Res. [Epub ahead of print]

87. Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE 3rd, Mann M, Dartois V, Rubin EJ. (2016) Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med. 22(5):531-8. doi: 10.1038/nm.4073.

88. Velasquez S, Malik S, Lutz SE, Scemes E, Eugenin EA. (2016) Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis. J Immunol. 196(10):4338-47. doi: 10.4049/jimmunol.1502440.

89. Shi L, Eugenin EA, Subbian S. (2016) http://www.ncbi.nlm.nih.gov/pubmed/27148269 Immunometabolism in Tuberculosis. Front Immunol. 7:150. doi: 10.3389/fimmu.2016.00150. eCollection 2016.

90. Calderon TM, Williams DW, Lopez L, Eugenin EA, Cheney L, Gaskill PJ, Veenstra M, Anastos K, Morgello S, Berman JW. (2017) Dopamine Increases CD14+CD16+ Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis. J Neuroimmune Pharmacol. 12(2):353-370. doi: 10.1007/s11481-017-9726-9. PMID: 2813371

91. Mishra BB, Lovewell RR, Olive AJ, Zhang G, Wang W, Eugenin E, Smith CM, Phuah JY, Long JE, Dubuke ML, Palace SG, Goguen JD, Baker RE, Nambi S, Mishra R, Booty MG, Baer CE, Shaffer SA, Dartois V, McCormick BA, Chen X, Sassetti CM. (2017) Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis. Nat Microbiol.  15;2:17072. doi: 10.1038/nmicrobiol.2017.72. PMID: 28504669

92. Megra BW, Eugenin EA, Berman JW. (2017) The Role of Shed PrPc in the neuropathogenesis of HIV Infection. J Immunol. 199(1):224-232. doi: 10.4049/jimmunol.1601041. PMID: 28533442.

93. Valdebenito S, Barreto A, Eugenin EA. (2017) The role of connexin and pannexin containing channels in the innate and acquired immune response. Biochim Biophys Acta. pii: S0005-2736(17)30176-1. doi: 10.1016/j.bbamem.2017.05.015. PMID: 28559189

94. Prevedel L, Ruel N, Castellano P, Smith C, Malik S, Villeux C, Bomsel M, Morgello S, Eugenin EA. (2019) Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy. Curr Protoc Cell Biol. 82(1): e64. doi: 10.1002/cpcb.64. PMID6386609

95. Castellano P, Prevedel L, Valdebenito S, Eugenin EA. (2019) HIV infection and latency induce a unique metabolic signature in human macrophages. Sci Rep. 2019 Mar 8;9(1):3941. doi: 10.1038/s41598-019-39898-5. PMID30850623

96. Ganor Y, Real F,   Sennepin A, Dutertre CA, Prevedel L, Xu L, Tudor D, Charmeteau B, Couedel-Courteille A, Marion S, Zenak AR, Jourdain JP, Zhou Z, Schmitt A, Capron C, Eugenin EA, Cheynier R, Revol M, Cristofari S, Hosmalin A, Bomsel M. (2019) HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy. Nat Microbiol. 4(4):633-644. doi: 10.1038/s41564-018-0335-z. PMID30718846.

97. Real F, Capron C, Sennepin A, Arrigucci R, Zhu A, Sannier G, Zheng J, Xu L, Massé JM, Greffe S, Cazabat M, Donoso M, Delobel P, Izopet J, Eugenin E.A., Gennaro ML, Rouveix E, Cramer Bordé E, Bomsel M. (2020) Platelets From HIV-infected Individuals on Antiretroviral Drug Therapy With Poor CD4 + T Cell Recovery Can Harbor Replication-Competent HIV Despite Viral Suppression. Science Translational Research. PMID: 32188724, DOI: 10.1126/scitranslmed.aat6263.

98. Gajardo-Gomez R., Santibanez C., Labra V.C., Gomez G., Eugenin E.A., and Orellana J. (2020) HIV-gp120 protein increases the function of connexin43 hemichannels and pannexin-1 channels in astrocytes: repercussions on astroglial function. I. Journal of Molecular Sciences, MDPI. In Press.

99. Lutgen V., Srinivas ND., Barbiana H., Richards M., Wallace J., Prevedel L., Razmpour R., Buzhdygan B., Ramirez S., Eugenin E.A., and Al-Harthi L. (2020) HIV infects astrocytes in vivo and support viral egress from the brain to the periphery" In Press. PLOS Pathogens.

100. Gorska AM and Eugenin E.A. (2020) Role of Glutamate in NeuroHIV and viral reservoirs. Front Cell Infect Microbiol. In Press.

101. Gajardo-Gomez R., Santibanez C., Labra V.C., Gomez G., Eugenin E.A., and Orellana J. (2020) HIV-gp120 protein increases the function of connexin43 hemichannels and pannexin-1 channels in astrocytes: repercussions on astroglial function. I. Journal of Molecular Sciences, MDPI. In Press.

102. S Valdebenito, A Audia, K.P.L. Bhat, G. Okafo, and E. A. Eugenin (2020) Tunneling nanotubes mediate adaptation of Glioblastoma Cells to temozolomide and ionizing radiation treatment. Cell-iScience. 23(9) 101450. PMID: 32882515, PMCID: PMC7476317, DOI: 10.1016/j.isci.2020.101450.

103.

103. Bohmwald K., Soto JA, Andrade-Parra C., Fernandez-Fierro A., Espinoza JA., Rios M., Eugenin E.A., Gonzalez PA., Opazo MC., Riedel CA., Kalergis. (2020) Lung pathology due to hRSV infection impairs Blood-Brain Barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS. Brain Behav. Immun, In Press.

104. Okafo G, Valdebenito S, Donoso M, Luu R, Ajasin D, Prideaux B, Gorantla S, Eugenin EA. (2020) Role of Tunneling Nanotube-like Structures during the Early Events of HIV Infection: Novel Features of Tissue Compartmentalization and Mechanism of HIV Spread. J Immunol. 2020 Nov 15;205(10):2726-2741. doi: 10.4049/jimmunol.2000803. PMID: 33037140.

105. Valdebenito S., D'Amico D., Eugenin E.A. (2020) Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools. Cancer Report. In Press. https://doi.org/10.1002/cnr2.1220.

106. Holzlechner M., Eugenin E.A., Prideaux B. (2020) Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer. Cancer Report. In Press https://doi.org/10.1002/cnr2.1229.

107. Ajasin D. and Eugenin E.A. (2020) HIV-tat: role in bystander toxicity. Front Cell Infect Microbiol. 10, 61. PMID: 32158701, PMCID: PMC7052126, DOI: 10.3389/fcimb.2020.00061. Manuscript Objective: Our third manuscript describes tat as a modulator of host genes.

108. Valdebenito S, Castellano P, Ajasin D, Eugenin EA. (2021) Astrocytes are HIV reservoirs in the brain: A cell type with poor HIV infectivity and replication but efficient cell-to-cell viral transfer. J Neurochem. 2021 Mar 2. doi: 10.1111/jnc.15336. Online ahead of print.PMID: 33655498.

109. León-Rivera R, Veenstra M, Donoso M, Tell E, Eugenin EA, Morgello S, Berman JW. (2021) Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART era. mBio. 2021 Mar 16;12(2):e03633-20. doi: 10.1128/mBio.03633-20.PMID: 33727362.

110. Gorska AM, Donoso M, Valdebenito S, Prideaux B, Queen S, Scemes E, Clements J, Eugenin E. (2021) Human immunodeficiency virus-1/simian immunodeficiency virus infection induces opening of pannexin-1 channels resulting in neuronal synaptic compromise: A novel therapeutic opportunity to prevent NeuroHIV. J Neurochem. 158(2):500-521. doi: 10.1111/jnc.15374. Epub 2021 May 9.PMID: 33899944.

111. Valdebenito S, Malik S, Luu R, Loudig O, Mitchell M, Okafo G, Bhat K, Prideaux B, Eugenin EA. (2021) Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions. Sci Rep. 15;11(1):14556. doi: 10.1038/s41598-021-93775-8.PMID: 34267246.

112. Malik S, Valdebenito S, D'Amico D, Prideaux B, Eugenin EA. (2021) HIV infection of astrocytes compromises inter-organelle interactions and inositol phosphate metabolism: A potential mechanism of bystander damage and viral reservoir survival. Prog Neurobiol. 2021 Nov;206:102157. doi: 10.1016/j.pneurobio. PMID: 34455020.

113. D'Amico D, Valdebenito S, Eugenin EA. (2021) The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus. Purinergic Signal. 2021 Sep 20. doi: 10.1007/s11302-021-09817-3. Online ahead of print.

114. Valdebenito S, Bessis S, Annane D, Lorin de la Grandmaison G, Cramer-Bordé E, Prideaux B, Eugenin EA, Bomsel M. (2021) COVID-19 Lung Pathogenesis in SARS-CoV-2 Autopsy Cases. Front Immunol. 2021 Oct 4;12:735922. doi: 10.3389/fimmu.2021.735922.

115. Luu R, Valdebenito S, Scemes E, Cibelli A, Spray DC, Rovegno M, Tichauer J, Cottignies-Calamarte A, Rosenberg A, Capron C, Belouzard S, Dubuisson J, Annane D, de la Grandmaison GL, Cramer-Bordé E, Bomsel M, Eugenin E. (2021) Pannexin-1 channel opening is critical for COVID-19 pathogenesis. iScience. 17;24(12):103478. doi: 10.1016/j.isci.2021.103478.

116. Shrestha J, Santerre M, Allen CNS, Arjona SP, Merali C, Mukerjee R, Chitrala KN, Park J, Bagashev A, Bui V, Eugenin EA, Merali S, Kaul M, Chin J, Sawaya BE. HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein. Front Aging Neurosci. 2022 May 9;14:811481. doi: 10.3389/fnagi.2022.811481. eCollection 2022.PMID: 35615594 .

117. Eugenin E, Camporesi E, Peracchia C. Direct Cell-Cell Communication via Membrane Pores, Gap Junction Channels, and Tunneling Nanotubes: Medical Relevance of Mitochondrial Exchange.

Int J Mol Sci. 2022 May 30;23(11):6133. doi: 10.3390/ijms23116133.PMID: 35682809 

118. Zhu A, Real F, Capron C, Rosenberg AR, Silvin A, Dunsmore G, Zhu J, Cottoignies-Callamarte A, Massé JM, Moine P, Bessis S, Godement M, Geri G, Chiche JD, Valdebenito S, Belouzard S, Dubuisson J, Lorin de la Grandmaison G, Chevret S, Ginhoux F, Eugenin EA, Annane D, Bordé EC, Bomsel M.CellInfection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19.

Mol Life Sci. 2022 Jun 16;79(7):365. doi: 10.1007/s00018-022-04318-x.PMID: 35708858 

119. Donoso M, D'Amico D, Valdebenito S, Hernandez CA, Prideaux B, Eugenin EA. Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain. Cells. 2022 Aug 2;11(15):2379. doi: 10.3390/cells11152379.PMID: 35954221